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Research Article
Relationship Between Serum Copper, Zinc Level and Tumour Aggressiveness in Invasive Cervical Cancer
Issue:
Volume 12, Issue 5, October 2024
Pages:
90-95
Received:
20 August 2024
Accepted:
5 September 2024
Published:
23 September 2024
Abstract: Background: Cervical cancer, a leading cause of cancer-related morbidity and mortality, exhibits considerable variability in aggressiveness. The role of trace elements such as copper and zinc in influencing tumor behavior and progression has garnered attention. This study investigates the relationship between serum copper and zinc levels and tumor aggressiveness in invasive cervical cancer. Methods: A cross-sectional comparative study was conducted among 150 women with invasive cervical cancer attending the outpatient department and Colposcopy Clinic of the Department of Gynecological Oncology, BSMMU, Dhaka, from April 2022 to March 2023. Participants were divided into two groups based on tumor aggressiveness: Group 1 (less aggressive) and Group 2 (more aggressive), with 75 women in each group. Serum copper and zinc levels were measured and analyzed for differences between groups. Result: Serum copper levels were significantly higher in Group 2 (152.31 ± 41.81 µg/dL) compared to Group 1 (139.31 ± 25.52 µg/dL) with a p-value of 0.023. Conversely, serum zinc levels were significantly lower in Group 2 (55.24 ± 28.13 µg/dL) compared to Group 1 (66.29 ± 31.58 µg/dL) with a p-value of 0.025. The copper/zinc ratio was significantly higher in Group 2 (2.76 ± 1.20) compared to Group 1 (2.10 ± 1.00) with a p-value of <0.001. Conclusion: Elevated serum copper levels and copper/zinc ratio, along with decreased zinc levels, are associated with more aggressive cervical cancer. These findings suggest that trace element imbalances may serve as biomarkers for assessing tumor aggressiveness and could inform future therapeutic strategies.
Abstract: Background: Cervical cancer, a leading cause of cancer-related morbidity and mortality, exhibits considerable variability in aggressiveness. The role of trace elements such as copper and zinc in influencing tumor behavior and progression has garnered attention. This study investigates the relationship between serum copper and zinc levels and tumor ...
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Research Article
Prevalence of Anemia Among Pregnant Women Attending ANC in Leku General Hospital, Sidama, Ethiopia
Mengistu Hailemariam Zenebe*
,
Berhanu Baruda,
Fetsum Bekele,
Gebeyew Mekonin,
Hanna Belete,
Yonas Mulugeta,
Zigiju Mossiye,
Yeshimebet Gebereselassie
Issue:
Volume 12, Issue 5, October 2024
Pages:
96-103
Received:
21 July 2024
Accepted:
13 August 2024
Published:
26 September 2024
Abstract: Introduction: Anemia is a global public health issue that affects people of all ages, although pregnant women and children under the age of five are the most vulnerable. During pregnancy, iron deficiency is associated with multiple adverse outcomes for both mothers and infants in developing countries. Nutritional anemia is also the most prevalent type of anemia in the world. This study's objective was to determine how common anemia was among pregnant women attending antenatal care at Leku General Hospital. Method: A cross-sectional study was conducted from July 25-August 15, 2022, on 284 pregnant women attending in Leku General Hospital. Pretested questionnaires based on interviews were used to collect socio-demographic information and related data. Hemoglobin concentration was determined using Beckman Coulter DxH 800 analyzer and hemoglobin concentration <11 g/dl was classified as anemic. Bivariate and multiple logistic regression analysis was used to determine the predictor's value for anemia. P<0.05 was considered statistically significant. Result: The prevalence of anemia among pregnant women was found to be 21.7% (95% CI: 16.7%-26.8%). Women who live in rural areas were revealed to be factors affecting pregnant women's anemia (AOR = 4.2, 95% CI: 1.97-9.10). Approximately half of the anemic pregnant women surveyed were found to have moderate anemia (Hb 7- 9.9 g/dl) with 55% and 7% severely anemic. The most important clinically relevant finding was that (65%) of anemic pregnant women were found to have microcytic and hypochromic anemia which is the most common type in pregnancy that occurs mostly due to iron deficiency. Conclusion: Compared to the national pooled data, this study finds anemia has a moderate impact on local public health. The related factors should be considered for improving rural community-based anemia management for pregnant women.
Abstract: Introduction: Anemia is a global public health issue that affects people of all ages, although pregnant women and children under the age of five are the most vulnerable. During pregnancy, iron deficiency is associated with multiple adverse outcomes for both mothers and infants in developing countries. Nutritional anemia is also the most prevalent t...
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Research Article
Clinical Characteristics and Causes of Perinatal Death Among Women Who Delivered at SekouToure Regional Referral Hospital, Mwanza Region, Northwestern Tanzania
Innocent Lutakyamilwa Kaiza*,
Emmiliana Dismas Mvungi,
Furaha Katende Munema,
Nakiete Samuel Machangu,
Ndakibae Gabriel Mabega
Issue:
Volume 12, Issue 5, October 2024
Pages:
104-109
Received:
11 September 2024
Accepted:
29 September 2024
Published:
18 October 2024
DOI:
10.11648/j.jgo.20241205.13
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Abstract: Background: Perinatal deaths and neonatal deaths are major public health concern worldwide. They are unexpected tragedy which brings bad experience to the pregnant mothers and the families in general. Occurrences of these deaths may be used to evaluate the quality of obstetric care given to pregnant women in the hospital. They shows good quality of obstetric care when they are low in number. Therefore, more efforts must be directed in preventing these deaths. Methods: This was a one-year retrospective descriptive hospital based study conducted in one of the tertiary regional referral hospital. Women who had perinatal deaths between the studied periods and meet the inclusion criteria were included. Results: There were 7336 deliveries in the study, 81.1% (n =5953) had vagina deliveries and 18.9% (n=1383) had Caesarean section. Total of 169 cases of perinatal deaths identified, making a rate of perinatal deaths of 23 cases per 1000 deliveries (2.3%). Among perinatal death 40% (n=67) were early neonatal deaths and there was an identified association between referral from lower health facilities with early neonatal deaths. Conclusion: The rate of perinatal deaths in this study was relatively low compared to other studies. This reflect the quality of obstetrics care pregnant women received in our facility. And most of these women with early neonatal deaths were referred to our facility from lower health facilities with complications.
Abstract: Background: Perinatal deaths and neonatal deaths are major public health concern worldwide. They are unexpected tragedy which brings bad experience to the pregnant mothers and the families in general. Occurrences of these deaths may be used to evaluate the quality of obstetric care given to pregnant women in the hospital. They shows good quality of...
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Research Article
Factors Associated with Cesarean Section in Primiparous Women at the Bernard Kouchner Communal Medical Centre in Coronthie, Conakry, Guinea
Leno Daniel William Athanase,
Conte Ibrahima*,
Tolno Tamba Julien,
Magassouba Mamoudou,
Lamah David,
Pindou Rence Carla Theresa,
Sy Telly
Issue:
Volume 12, Issue 5, October 2024
Pages:
110-117
Received:
4 August 2024
Accepted:
29 September 2024
Published:
18 October 2024
DOI:
10.11648/j.jgo.20241205.14
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Views:
Abstract: Objective: to analyse the factors associated with Caesarean section in primiparous women. Methods: This was a 12-month (1 January to 31 December 2022) retrospective case-control study conducted at the Bernard Kouchner Communal Medical Centre (CMC) in Coronthie. Correctly completed records of primiparous women with a singleton pregnancy were included, with a live foetus in cephalic presentation having been delivered (by Caesarean section or vaginal delivery) from 28 weeks' gestation with a weight ≥ 1000 g. The "cases" consisted of records from primiparous women who had undergone caesarean section. The "controls" were composed by matching each "case" with the record of a patient who had undergone vaginal delivery, according to the order in the delivery register. Socio-demographic, clinical and obstetric characteristics were analysed and compared. A univariate analysis comparing cases to controls and a multivariate analysis looking for an association between maternal determinants were performed. Results: The prevalence of caesarean section in primiparous women was 31%. The average age of primiparous women was 24 ± 5 years. The 20-24 age group was the most represented in both groups, with 35% of caesareans and 42% of vaginal deliveries. The factors significantly associated with caesarean section in primiparous women were advanced maternal age (OR=1.13 CI=1.07-1.20), prolonged pregnancy (OR=25.1 CI =3.23 - 5.40), arterial hypertension (OR=4.98 CI= 2.24 -11.6), premature rupture of membranes (OR= 4.25 CI: 2.27 - 8.05), haemorrhagic complications (OR=8.56 CI=3.05 - 26.6), foetal distress (OR=68.4 CI=18.3 - 45.1) and macrosomia (OR=12.7 CI= 4.83 - 38.6). Conclusion: correct antenatal care and delivery by qualified personnel could help prevent some of these factors and thus reduce the caesarean section rate among primiparous women in our health facility.
Abstract: Objective: to analyse the factors associated with Caesarean section in primiparous women. Methods: This was a 12-month (1 January to 31 December 2022) retrospective case-control study conducted at the Bernard Kouchner Communal Medical Centre (CMC) in Coronthie. Correctly completed records of primiparous women with a singleton pregnancy were include...
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