Research Article
Relationship Between Serum Copper, Zinc Level and Tumour Aggressiveness in Invasive Cervical Cancer
Issue:
Volume 12, Issue 5, October 2024
Pages:
90-95
Received:
20 August 2024
Accepted:
5 September 2024
Published:
23 September 2024
DOI:
10.11648/j.jgo.20241205.11
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Abstract: Background: Cervical cancer, a leading cause of cancer-related morbidity and mortality, exhibits considerable variability in aggressiveness. The role of trace elements such as copper and zinc in influencing tumor behavior and progression has garnered attention. This study investigates the relationship between serum copper and zinc levels and tumor aggressiveness in invasive cervical cancer. Methods: A cross-sectional comparative study was conducted among 150 women with invasive cervical cancer attending the outpatient department and Colposcopy Clinic of the Department of Gynecological Oncology, BSMMU, Dhaka, from April 2022 to March 2023. Participants were divided into two groups based on tumor aggressiveness: Group 1 (less aggressive) and Group 2 (more aggressive), with 75 women in each group. Serum copper and zinc levels were measured and analyzed for differences between groups. Result: Serum copper levels were significantly higher in Group 2 (152.31 ± 41.81 µg/dL) compared to Group 1 (139.31 ± 25.52 µg/dL) with a p-value of 0.023. Conversely, serum zinc levels were significantly lower in Group 2 (55.24 ± 28.13 µg/dL) compared to Group 1 (66.29 ± 31.58 µg/dL) with a p-value of 0.025. The copper/zinc ratio was significantly higher in Group 2 (2.76 ± 1.20) compared to Group 1 (2.10 ± 1.00) with a p-value of <0.001. Conclusion: Elevated serum copper levels and copper/zinc ratio, along with decreased zinc levels, are associated with more aggressive cervical cancer. These findings suggest that trace element imbalances may serve as biomarkers for assessing tumor aggressiveness and could inform future therapeutic strategies.
Abstract: Background: Cervical cancer, a leading cause of cancer-related morbidity and mortality, exhibits considerable variability in aggressiveness. The role of trace elements such as copper and zinc in influencing tumor behavior and progression has garnered attention. This study investigates the relationship between serum copper and zinc levels and tumor ...
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Research Article
Prevalence of Anemia Among Pregnant Women Attending ANC in Leku General Hospital, Sidama, Ethiopia
Mengistu Hailemariam Zenebe*
,
Berhanu Baruda,
Fetsum Bekele,
Gebeyew Mekonin,
Hanna Belete,
Yonas Mulugeta,
Zigiju Mossiye,
Yeshimebet Gebereselassie
Issue:
Volume 12, Issue 5, October 2024
Pages:
96-103
Received:
21 July 2024
Accepted:
13 August 2024
Published:
26 September 2024
DOI:
10.11648/j.jgo.20241205.12
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Abstract: Introduction: Anemia is a global public health issue that affects people of all ages, although pregnant women and children under the age of five are the most vulnerable. During pregnancy, iron deficiency is associated with multiple adverse outcomes for both mothers and infants in developing countries. Nutritional anemia is also the most prevalent type of anemia in the world. This study's objective was to determine how common anemia was among pregnant women attending antenatal care at Leku General Hospital. Method: A cross-sectional study was conducted from July 25-August 15, 2022, on 284 pregnant women attending in Leku General Hospital. Pretested questionnaires based on interviews were used to collect socio-demographic information and related data. Hemoglobin concentration was determined using Beckman Coulter DxH 800 analyzer and hemoglobin concentration <11 g/dl was classified as anemic. Bivariate and multiple logistic regression analysis was used to determine the predictor's value for anemia. P<0.05 was considered statistically significant. Result: The prevalence of anemia among pregnant women was found to be 21.7% (95% CI: 16.7%-26.8%). Women who live in rural areas were revealed to be factors affecting pregnant women's anemia (AOR = 4.2, 95% CI: 1.97-9.10). Approximately half of the anemic pregnant women surveyed were found to have moderate anemia (Hb 7- 9.9 g/dl) with 55% and 7% severely anemic. The most important clinically relevant finding was that (65%) of anemic pregnant women were found to have microcytic and hypochromic anemia which is the most common type in pregnancy that occurs mostly due to iron deficiency. Conclusion: Compared to the national pooled data, this study finds anemia has a moderate impact on local public health. The related factors should be considered for improving rural community-based anemia management for pregnant women.
Abstract: Introduction: Anemia is a global public health issue that affects people of all ages, although pregnant women and children under the age of five are the most vulnerable. During pregnancy, iron deficiency is associated with multiple adverse outcomes for both mothers and infants in developing countries. Nutritional anemia is also the most prevalent t...
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