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Conservative Management, Follow-up and Perinatal Outcomes After Gestational Trophoblastic Disease with Coexistent Normal Fetus: Case Report

Received: 23 January 2019     Accepted: 30 March 2019     Published: 22 April 2019
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Abstract

Background: Gestational trophoblastic disease (GTD) is the consequence of a genetic alteration that happens during fecundation. Is the term used to describe malignant lesions that originates in the chorionic villi an extra villous trophoblast. Molar pregnancies can be subdivided into complete (CM) and partial moles (PM) based on genetic and histopathological features. Case report: 23-year old patient, who presents an ultrasound which revealed a singleton pregnancy with no fetal structural abnormalities, and fetal biometry consistent with gestational age (16w + 6d). There was a placenta with focal areas of enlargement associated with numerous lucent cyst, and normal amniotic fluid, compatible with partial molar pregnancy in association with a normal fetus. After risks of subsequent fetal and maternal complications were explained to the patient and her family, it was elected to continue with her pregnancy; patient went under cesarean delivery at 31w 3d because low amniotic fluid levels (oligohydramnios) and abnormal fetal well-being tests.

Published in Journal of Gynecology and Obstetrics (Volume 7, Issue 2)
DOI 10.11648/j.jgo.20190702.12
Page(s) 36-40
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Gestational Trophoblastic Disease, Partial Mole, Partial Mole Associated with Normal Fetus

References
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[2] Hui P, Buza N, Murphy KM, Ronnett BM. Hydatidiform Moles: Genetic Basis and Precision Diagnosis. Annu Rev Pathol. 2017 Jan 24;12:449-485.
[3] Protocolos SEGO. Embarazo molar. Prog Obstet Ginecol 2004; 47 (8): 400-4.
[4] Juárez Azpilcueta A, Islas Domínguez L, Duran Padilla MA. Mola Hidatiforme Parcial con feto vivo del segundo trimestre. Rev Chil Obstet Ginecolg 2010; 75(2): 137-139.
[5] Surendran S, Thomas T, Vishnupriya VS. Partial Molar Pregnancy with a Normal Fetus with Complete Placenta Previa. J Obstet Gynaecol India 2018 Jun; 68(3):227.228.
[6] Galaz-Montoya CI, Razo Aguilera G, Grether-González P, Aguinaga-Ríos M. Aspectos genéticos de la mola hidatiforme. Perinatol Reprodu Hum 2015; 29(3): 113-117
[7] Duffy L, Zhang L, Sheath K, Love DR, George AM. The Diagnosis of Choriocarcinoma in Molar Pregnancies: A Revised Approach in Clinical Testing. J Clin Med Res. 2015 Dec;7(12):961-6
[8] Morales García V, Bautista Gómez E, Vásquez Santiago E, Santos Pérez U. Embarazo molar parcial: reporte de un caso y revisión de la bibliografía. Ginecol Obstet Mex 2011;79(7):432-435.
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[10] Sak ME, Soydinc HE, Evsen MS, Firat U. Diploide karyotype partial mole coexisting with live term fetus-case report and reviewd of the world literature. Ginekol Pol. 2012 Oct;83(10):789-91
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[15] Ramani B et al. Living fetus without congenital malformation in a singleton partial hydatiform molar pregnancy: a case report and review of the literature. In J Reprod Contracept Obstet Gynecol. 2014 Dec: 3(4): 1130-1133.
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  • APA Style

    Herrera-Ortiz Alejandra, Barrita-Domínguez Isela Juliana, Morales-Domínguez Liliana, Rojas-Camacho Francisco Miguel. (2019). Conservative Management, Follow-up and Perinatal Outcomes After Gestational Trophoblastic Disease with Coexistent Normal Fetus: Case Report. Journal of Gynecology and Obstetrics, 7(2), 36-40. https://doi.org/10.11648/j.jgo.20190702.12

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    ACS Style

    Herrera-Ortiz Alejandra; Barrita-Domínguez Isela Juliana; Morales-Domínguez Liliana; Rojas-Camacho Francisco Miguel. Conservative Management, Follow-up and Perinatal Outcomes After Gestational Trophoblastic Disease with Coexistent Normal Fetus: Case Report. J. Gynecol. Obstet. 2019, 7(2), 36-40. doi: 10.11648/j.jgo.20190702.12

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    AMA Style

    Herrera-Ortiz Alejandra, Barrita-Domínguez Isela Juliana, Morales-Domínguez Liliana, Rojas-Camacho Francisco Miguel. Conservative Management, Follow-up and Perinatal Outcomes After Gestational Trophoblastic Disease with Coexistent Normal Fetus: Case Report. J Gynecol Obstet. 2019;7(2):36-40. doi: 10.11648/j.jgo.20190702.12

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  • @article{10.11648/j.jgo.20190702.12,
      author = {Herrera-Ortiz Alejandra and Barrita-Domínguez Isela Juliana and Morales-Domínguez Liliana and Rojas-Camacho Francisco Miguel},
      title = {Conservative Management, Follow-up and Perinatal Outcomes After Gestational Trophoblastic Disease with Coexistent Normal Fetus: Case Report},
      journal = {Journal of Gynecology and Obstetrics},
      volume = {7},
      number = {2},
      pages = {36-40},
      doi = {10.11648/j.jgo.20190702.12},
      url = {https://doi.org/10.11648/j.jgo.20190702.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20190702.12},
      abstract = {Background: Gestational trophoblastic disease (GTD) is the consequence of a genetic alteration that happens during fecundation. Is the term used to describe malignant lesions that originates in the chorionic villi an extra villous trophoblast. Molar pregnancies can be subdivided into complete (CM) and partial moles (PM) based on genetic and histopathological features. Case report: 23-year old patient, who presents an ultrasound which revealed a singleton pregnancy with no fetal structural abnormalities, and fetal biometry consistent with gestational age (16w + 6d). There was a placenta with focal areas of enlargement associated with numerous lucent cyst, and normal amniotic fluid, compatible with partial molar pregnancy in association with a normal fetus. After risks of subsequent fetal and maternal complications were explained to the patient and her family, it was elected to continue with her pregnancy; patient went under cesarean delivery at 31w 3d because low amniotic fluid levels (oligohydramnios) and abnormal fetal well-being tests.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Conservative Management, Follow-up and Perinatal Outcomes After Gestational Trophoblastic Disease with Coexistent Normal Fetus: Case Report
    AU  - Herrera-Ortiz Alejandra
    AU  - Barrita-Domínguez Isela Juliana
    AU  - Morales-Domínguez Liliana
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    N1  - https://doi.org/10.11648/j.jgo.20190702.12
    DO  - 10.11648/j.jgo.20190702.12
    T2  - Journal of Gynecology and Obstetrics
    JF  - Journal of Gynecology and Obstetrics
    JO  - Journal of Gynecology and Obstetrics
    SP  - 36
    EP  - 40
    PB  - Science Publishing Group
    SN  - 2376-7820
    UR  - https://doi.org/10.11648/j.jgo.20190702.12
    AB  - Background: Gestational trophoblastic disease (GTD) is the consequence of a genetic alteration that happens during fecundation. Is the term used to describe malignant lesions that originates in the chorionic villi an extra villous trophoblast. Molar pregnancies can be subdivided into complete (CM) and partial moles (PM) based on genetic and histopathological features. Case report: 23-year old patient, who presents an ultrasound which revealed a singleton pregnancy with no fetal structural abnormalities, and fetal biometry consistent with gestational age (16w + 6d). There was a placenta with focal areas of enlargement associated with numerous lucent cyst, and normal amniotic fluid, compatible with partial molar pregnancy in association with a normal fetus. After risks of subsequent fetal and maternal complications were explained to the patient and her family, it was elected to continue with her pregnancy; patient went under cesarean delivery at 31w 3d because low amniotic fluid levels (oligohydramnios) and abnormal fetal well-being tests.
    VL  - 7
    IS  - 2
    ER  - 

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Author Information
  • Department of Gynecology and Obstetrics at General Hospital “Dr. Manuel Gea González”, México City, Mexico

  • Department of Maternal-Fetal Medicine at General Hospital “Dr. Manuel Gea González”, México City, Mexico

  • Department of Hysteroscopy at General Hospital “Dr. Manuel Gea González”, México City, Mexico

  • Department of Gynecology and Obstetrics at General Hospital “Dr. Manuel Gea González”, México City, Mexico

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