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Prospects for the Treatment of Endometriosis: The Effect of Immune Peptides on the Reactivation of Immune Surveillance over Ectopic Endometrial Cells

Received: 13 September 2020     Accepted: 29 September 2020     Published: 13 October 2020
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Abstract

Background. Genital endometriosis (GE) remains a significantly common disease, occurring in 0.5-5% of fertile women and in 25-40% of women with infertility. In patients with GE, there is a decrease in apoptosis in endometrial cells compared to healthy women, even more pronounced in ectopic foci, as a result of which their proliferative activity increases and the ability to abnormal implantation increases. Objective. Our task was to study the patterns of interaction of immune cells with ectopic endometrial cells, as well as to determine the molecular biological levers of influence on immune surveillance in endometriosis. Given the ability of ectopic cells to change the microenvironment in their favor, we aimed to find an effective tool to restore immune surveillance of endometrioma and thus offer a promising treatment for the disease. Method. For the purpose of writing this review article, we used the method of selection and analysis of scientific publications with open access. Results. The use of immune peptides in endometriosis, which are capable of activating regulatory macrophages and stimulating the recruitment of T-lymphocytes, opens up new possibilities for controlling the disease. Arecur, which contains immune peptides, including defensins and RJP-1, tunes immune cells to maximize their productivity against ectopic tissue, potentially creating conditions for the prevention of endometriosis-associated ovarian cancer. Conclusion. The use of immune peptides in endometriosis quite predictably contributes to more efficient work of local immunity. Immune cells potentiated with peptides not only independently attack and separate the intercellular connections in the endometrioma, but also provoke apoptosis of ectopic cells. The use of immune peptides in endometriosis opens up new prospects for increasing the effectiveness of treatment and prevention of this disease.

Published in Journal of Gynecology and Obstetrics (Volume 8, Issue 5)
DOI 10.11648/j.jgo.20200805.14
Page(s) 148-153
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Endometriosis, Ectopic Cells, Immune Surveillance, Immune Peptides, Arecur

References
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  • APA Style

    Natalia Zakharenko, Oleksii Tatskiy, Sergii Konovalenko. (2020). Prospects for the Treatment of Endometriosis: The Effect of Immune Peptides on the Reactivation of Immune Surveillance over Ectopic Endometrial Cells. Journal of Gynecology and Obstetrics, 8(5), 148-153. https://doi.org/10.11648/j.jgo.20200805.14

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    ACS Style

    Natalia Zakharenko; Oleksii Tatskiy; Sergii Konovalenko. Prospects for the Treatment of Endometriosis: The Effect of Immune Peptides on the Reactivation of Immune Surveillance over Ectopic Endometrial Cells. J. Gynecol. Obstet. 2020, 8(5), 148-153. doi: 10.11648/j.jgo.20200805.14

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    AMA Style

    Natalia Zakharenko, Oleksii Tatskiy, Sergii Konovalenko. Prospects for the Treatment of Endometriosis: The Effect of Immune Peptides on the Reactivation of Immune Surveillance over Ectopic Endometrial Cells. J Gynecol Obstet. 2020;8(5):148-153. doi: 10.11648/j.jgo.20200805.14

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  • @article{10.11648/j.jgo.20200805.14,
      author = {Natalia Zakharenko and Oleksii Tatskiy and Sergii Konovalenko},
      title = {Prospects for the Treatment of Endometriosis: The Effect of Immune Peptides on the Reactivation of Immune Surveillance over Ectopic Endometrial Cells},
      journal = {Journal of Gynecology and Obstetrics},
      volume = {8},
      number = {5},
      pages = {148-153},
      doi = {10.11648/j.jgo.20200805.14},
      url = {https://doi.org/10.11648/j.jgo.20200805.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20200805.14},
      abstract = {Background. Genital endometriosis (GE) remains a significantly common disease, occurring in 0.5-5% of fertile women and in 25-40% of women with infertility. In patients with GE, there is a decrease in apoptosis in endometrial cells compared to healthy women, even more pronounced in ectopic foci, as a result of which their proliferative activity increases and the ability to abnormal implantation increases. Objective. Our task was to study the patterns of interaction of immune cells with ectopic endometrial cells, as well as to determine the molecular biological levers of influence on immune surveillance in endometriosis. Given the ability of ectopic cells to change the microenvironment in their favor, we aimed to find an effective tool to restore immune surveillance of endometrioma and thus offer a promising treatment for the disease. Method. For the purpose of writing this review article, we used the method of selection and analysis of scientific publications with open access. Results. The use of immune peptides in endometriosis, which are capable of activating regulatory macrophages and stimulating the recruitment of T-lymphocytes, opens up new possibilities for controlling the disease. Arecur, which contains immune peptides, including defensins and RJP-1, tunes immune cells to maximize their productivity against ectopic tissue, potentially creating conditions for the prevention of endometriosis-associated ovarian cancer. Conclusion. The use of immune peptides in endometriosis quite predictably contributes to more efficient work of local immunity. Immune cells potentiated with peptides not only independently attack and separate the intercellular connections in the endometrioma, but also provoke apoptosis of ectopic cells. The use of immune peptides in endometriosis opens up new prospects for increasing the effectiveness of treatment and prevention of this disease.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Prospects for the Treatment of Endometriosis: The Effect of Immune Peptides on the Reactivation of Immune Surveillance over Ectopic Endometrial Cells
    AU  - Natalia Zakharenko
    AU  - Oleksii Tatskiy
    AU  - Sergii Konovalenko
    Y1  - 2020/10/13
    PY  - 2020
    N1  - https://doi.org/10.11648/j.jgo.20200805.14
    DO  - 10.11648/j.jgo.20200805.14
    T2  - Journal of Gynecology and Obstetrics
    JF  - Journal of Gynecology and Obstetrics
    JO  - Journal of Gynecology and Obstetrics
    SP  - 148
    EP  - 153
    PB  - Science Publishing Group
    SN  - 2376-7820
    UR  - https://doi.org/10.11648/j.jgo.20200805.14
    AB  - Background. Genital endometriosis (GE) remains a significantly common disease, occurring in 0.5-5% of fertile women and in 25-40% of women with infertility. In patients with GE, there is a decrease in apoptosis in endometrial cells compared to healthy women, even more pronounced in ectopic foci, as a result of which their proliferative activity increases and the ability to abnormal implantation increases. Objective. Our task was to study the patterns of interaction of immune cells with ectopic endometrial cells, as well as to determine the molecular biological levers of influence on immune surveillance in endometriosis. Given the ability of ectopic cells to change the microenvironment in their favor, we aimed to find an effective tool to restore immune surveillance of endometrioma and thus offer a promising treatment for the disease. Method. For the purpose of writing this review article, we used the method of selection and analysis of scientific publications with open access. Results. The use of immune peptides in endometriosis, which are capable of activating regulatory macrophages and stimulating the recruitment of T-lymphocytes, opens up new possibilities for controlling the disease. Arecur, which contains immune peptides, including defensins and RJP-1, tunes immune cells to maximize their productivity against ectopic tissue, potentially creating conditions for the prevention of endometriosis-associated ovarian cancer. Conclusion. The use of immune peptides in endometriosis quite predictably contributes to more efficient work of local immunity. Immune cells potentiated with peptides not only independently attack and separate the intercellular connections in the endometrioma, but also provoke apoptosis of ectopic cells. The use of immune peptides in endometriosis opens up new prospects for increasing the effectiveness of treatment and prevention of this disease.
    VL  - 8
    IS  - 5
    ER  - 

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Author Information
  • Endocrine Gynecology Department, NAMS Ukraine Institute of Pediatrics, Obstetrics and Gynecology, Kyiv, Ukraine

  • Department of Research and Development, International Biotherapy Institute, Kyiv, Ukraine

  • Department of Research and Development, International Biotherapy Institute, Kyiv, Ukraine

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