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Obesity and Endometrial Cancer: Increase in Frequency over a Period of 44 Years

Received: 7 October 2020     Accepted: 19 October 2020     Published: 30 October 2020
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Abstract

To draw attention to the increase in the frequency of endometrial cancer (CE) in recent decades and its association with overweight and obesity in a highly specialized institution. Retrospective study of patients with EC treated in the Oncology Service (OS) General Hospital of Mexico (GHM), in the years 2000 to 2017, obtaining information related to some risk factors and their classification. The data were compared with a previous study from the years 1966-1993. Of the record of 1,045 EC treated during the studied time of 44 years, 785 corresponded to the period 2000-2017 and 260 to the previous report, which meant an increase of 200% for this disease. Of gynecological cancers, the EC figures increased from 17.9% in 2010-2011 to 29.4% in 2016-2017 (p=0.0001). Overweight and obesity were in 572/785 (72.8%) of the current series vs. 120/260 (46.1%) of the previous series (p<0.05). An increase of 19% to 28% was found in women younger than 48 years when comparing the periods 2000 - 2009 vs. 2010-2017 (p=0.011); 119/389 classified as stage I, (30.5%) had risk factors for tumor recurrence and 378/898 (42.0%) had advanced malignancies. An increase in CE reported in this series and its association with overweight and obesity, may highlight the public health problem that this association represents in our country.

Published in Journal of Gynecology and Obstetrics (Volume 8, Issue 6)
DOI 10.11648/j.jgo.20200806.12
Page(s) 161-165
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Obesity, Endometrial, Cancer, Increase, Frequency

References
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[2] Cancer Facts and Figures. American Cancer Society. 2018. Pag. 4.
[3] Mexico. Source Globocan 2018. Number of new cases both sexes. International Agency for Research on Cancer. World Health Organization. 2018, p: 1-2.
[4] Fernández CSB, Leon AG, Herrera TMC, et al. Perfil Epidemiológico de los tumores Malignos en México. Dirección General de Epidemiología (SINAIS/SINAVE/DGE/Salud). México D. F. Secretaría de Salud; 2011. p. 46-122.
[5] Onstad AM, Schmandt ER, and Lu HK. Addressing de Role of Obesity. Endometrial Cancer Risk, Prevention, and treatment. J Clin Oncol. 2016; 34: 4225-4230. doi: 10.1200/JCO.2016.69.4638.
[6] Nevadunsky SN, Arsdale Va, Strickler DH, Moadel A, et al, Obesity and Age at Diagnosis of Endometrial Cancer. Obstet Gynecol. 2014; 124: 300-306. Doi: 10.1097/AOG.0000000000000381.
[7] Himbert C, Delphan M, Scherer D, Bowers WB, Stephen, and Cornelia M. Hursting C. Signals from the Adipose Microenvironment and the Obesity Cancer Link A Systematic Review. Cancer Prev Res. 2017; 10: 494–506. doi: 10.1158/1940-6207.CAPR-16-0322.
[8] Campos NI, Cuevas NL, González CLD, Hernández BL, et al. Epidemiología de la obesidad y sus principales comorbilidades en México. En: La Obesidad en México. Estado de la política pública y recomendaciones para su prevención y control. Editores: Juan Ángel Rivera Dommarco, Maranta Colchero y col. Instituto Nacional de Salud Pública. México 2018. p: 31-38.
[9] Encuesta Nacional de Salud y Nutrición 2018. Presentación de resultados. ensanut.insp.mx>informes>ensanut_2018_presentacion_resultados. 2019: p. 41.
[10] Uterine Neoplasms. NCCN clinical Practice Guidelines in Oncology (NCCN Guidelines) 2019. Endo 4-10.
[11] Creasman TW, Scott MD. Adenocarcinoma of the Uterine Corpus. In: Clinical Gynecologic Oncology Eds. Philip P Disaia, William T Creasman et al. Elsevier Ninth Ed. Philadelphia 2018. P. 131-135.
[12] Torres LA, Plata NP, Cruz TF, et al. Cáncer ginecológico, 1983-1984. Frecuencia relativa y resultados del tratamiento. Unidad de Oncología. Hospital General de México. Rev Med Hosp Gen (Mex) 1987; 50: 169-177.
[13] Torres LA, Amoretti C, Morgan OF. Cáncer ginecológico: evolución de su frecuencia relativa en una Institución de alta especialidad. Gac Mex Oncol (GAMO) 2014; 13: 222-228.
[14] Torres LA, Flores VA, Rojo HG, Román BE, et al. Cáncer del endometrio en el Hospital General de México: 27 años de experiencia. Rev Inst Nal Cancerol (Mex) 1998; 44: 124-133.
[15] Islami F, Torre AL, Drope MJ, Ward ME, et al. Gobal Cancer in Women: Cancer Control Priorities. Cancer Epidemiol Biomarkers Prev. 2017; 26: 458-70. doi: 10.1158/1055-9965.EPI-16-0871.
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  • APA Style

    Alfonso Torres Lobaton, Rosalva Barra Martinez, Elisa Paola Jimenez Arroyo, Juan Carlos Oliva Posada, Carla America Suarez Juarez, et al. (2020). Obesity and Endometrial Cancer: Increase in Frequency over a Period of 44 Years. Journal of Gynecology and Obstetrics, 8(6), 161-165. https://doi.org/10.11648/j.jgo.20200806.12

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    ACS Style

    Alfonso Torres Lobaton; Rosalva Barra Martinez; Elisa Paola Jimenez Arroyo; Juan Carlos Oliva Posada; Carla America Suarez Juarez, et al. Obesity and Endometrial Cancer: Increase in Frequency over a Period of 44 Years. J. Gynecol. Obstet. 2020, 8(6), 161-165. doi: 10.11648/j.jgo.20200806.12

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    AMA Style

    Alfonso Torres Lobaton, Rosalva Barra Martinez, Elisa Paola Jimenez Arroyo, Juan Carlos Oliva Posada, Carla America Suarez Juarez, et al. Obesity and Endometrial Cancer: Increase in Frequency over a Period of 44 Years. J Gynecol Obstet. 2020;8(6):161-165. doi: 10.11648/j.jgo.20200806.12

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  • @article{10.11648/j.jgo.20200806.12,
      author = {Alfonso Torres Lobaton and Rosalva Barra Martinez and Elisa Paola Jimenez Arroyo and Juan Carlos Oliva Posada and Carla America Suarez Juarez and Fred Morgan Ortiz},
      title = {Obesity and Endometrial Cancer: Increase in Frequency over a Period of 44 Years},
      journal = {Journal of Gynecology and Obstetrics},
      volume = {8},
      number = {6},
      pages = {161-165},
      doi = {10.11648/j.jgo.20200806.12},
      url = {https://doi.org/10.11648/j.jgo.20200806.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20200806.12},
      abstract = {To draw attention to the increase in the frequency of endometrial cancer (CE) in recent decades and its association with overweight and obesity in a highly specialized institution. Retrospective study of patients with EC treated in the Oncology Service (OS) General Hospital of Mexico (GHM), in the years 2000 to 2017, obtaining information related to some risk factors and their classification. The data were compared with a previous study from the years 1966-1993. Of the record of 1,045 EC treated during the studied time of 44 years, 785 corresponded to the period 2000-2017 and 260 to the previous report, which meant an increase of 200% for this disease. Of gynecological cancers, the EC figures increased from 17.9% in 2010-2011 to 29.4% in 2016-2017 (p=0.0001). Overweight and obesity were in 572/785 (72.8%) of the current series vs. 120/260 (46.1%) of the previous series (p<0.05). An increase of 19% to 28% was found in women younger than 48 years when comparing the periods 2000 - 2009 vs. 2010-2017 (p=0.011); 119/389 classified as stage I, (30.5%) had risk factors for tumor recurrence and 378/898 (42.0%) had advanced malignancies. An increase in CE reported in this series and its association with overweight and obesity, may highlight the public health problem that this association represents in our country.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Obesity and Endometrial Cancer: Increase in Frequency over a Period of 44 Years
    AU  - Alfonso Torres Lobaton
    AU  - Rosalva Barra Martinez
    AU  - Elisa Paola Jimenez Arroyo
    AU  - Juan Carlos Oliva Posada
    AU  - Carla America Suarez Juarez
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    JF  - Journal of Gynecology and Obstetrics
    JO  - Journal of Gynecology and Obstetrics
    SP  - 161
    EP  - 165
    PB  - Science Publishing Group
    SN  - 2376-7820
    UR  - https://doi.org/10.11648/j.jgo.20200806.12
    AB  - To draw attention to the increase in the frequency of endometrial cancer (CE) in recent decades and its association with overweight and obesity in a highly specialized institution. Retrospective study of patients with EC treated in the Oncology Service (OS) General Hospital of Mexico (GHM), in the years 2000 to 2017, obtaining information related to some risk factors and their classification. The data were compared with a previous study from the years 1966-1993. Of the record of 1,045 EC treated during the studied time of 44 years, 785 corresponded to the period 2000-2017 and 260 to the previous report, which meant an increase of 200% for this disease. Of gynecological cancers, the EC figures increased from 17.9% in 2010-2011 to 29.4% in 2016-2017 (p=0.0001). Overweight and obesity were in 572/785 (72.8%) of the current series vs. 120/260 (46.1%) of the previous series (p<0.05). An increase of 19% to 28% was found in women younger than 48 years when comparing the periods 2000 - 2009 vs. 2010-2017 (p=0.011); 119/389 classified as stage I, (30.5%) had risk factors for tumor recurrence and 378/898 (42.0%) had advanced malignancies. An increase in CE reported in this series and its association with overweight and obesity, may highlight the public health problem that this association represents in our country.
    VL  - 8
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Author Information
  • Oncology Unit, General Hospital of Mexico, Mexico City, Mexico

  • Oncology Unit, General Hospital of Mexico, Mexico City, Mexico

  • Oncology Unit, General Hospital of Mexico, Mexico City, Mexico

  • Oncology Unit, General Hospital of Mexico, Mexico City, Mexico

  • Diamond Tower, Metropolitan Angel’s Hospital, Mexico City, Mexico

  • Research Center in Health Sciences, Autonomous University of Sinaloa, Mexico City, Mexico

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