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Average and Variation of Oocyte Counts in Women Undergoing in Vitro Fertilization

Received: 25 January 2021     Accepted: 18 February 2021     Published: 4 March 2021
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Abstract

Artificial reproductive technology (ART) has become a standard treatment for patients with infertility. However the cost is burdensome to infertile patients in some countries. Moreover aging is a critical factor for infertile patients and is accompanied by higher risk of condition and counts of oocytes. In planning ART for a patient, there are two patterns of oocyte pick-up (OPU) method: One is to transfer all the embros which are obtained from one OPU. Then next OPU will be performed when she fails to get pregnant despite using up all embryos. The other method is to repeat several consecutive OPUs until sufficient stock of embryos. The sufficiency depends on age, serum AMH level, etc. This study investigates the deviation in the number of oocytes collected by OPU in infertile patients who received multiple OPU within 1 year. The number of oocytes increased as the average number of oocytes increased. However, the ratio of standard deviation/average decreased. The frequency of required OPU depends on the pregnancy rate per embryo, the background of the patient, and the number of eggs collected at the first or second OPU. Thus, the analysis will reduce their mental and economic burden. Further studies with large-scale data are needed to determine the ideal frequency of OPU.

Published in Journal of Gynecology and Obstetrics (Volume 9, Issue 2)
DOI 10.11648/j.jgo.20210902.11
Page(s) 31-35
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Infertility, Artificial Reproductive Technology (ART), Oocyte Pick up (OPU), Cost, Variation of Oocyte Count

References
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[2] S. Iliodromiti, T. W. Kelsey, O. Wu, R. A. Anderson, S. M. Nelson, The predictive accuracy of anti-Mullerian hormone for live birth after assisted conception: a systematic review and meta-analysis of the literature, Hum Reprod Update 20 (4) (2014) 560-70.
[3] S. L. Broer, F. J. Broekmans, J. S. Laven, B. C. Fauser, Anti-Mullerian hormone: ovarian reserve testing and its potential clinical implications, Hum Reprod Update 20 (5) (2014) 688-701.
[4] N A. Dennis, L. A. Houghton, G. T. Jones, A. M. van Rij, K. Morgan, I. S. McLennan, The level of serum anti-Mullerian hormone correlates with vitamin D status in men and women but not in boys, J Clin Endocrinol Metab 97 (7) (2012) 2450-5.
[5] N. Suzuki, N. Yoshioka, S. Takae, Y. Sugishita, M. Tamura, S. Hashimoto, Y. Morimoto, K. Kawamura, Successful fertility preservation following ovarian tissue vitrification in patients with primary ovarian insufficiency, Hum Reprod 30 (3) (2015) 608-15.
[6] I. A. van Rooij, F. J. Broekmans, E. R. te Velde, B. C. Fauser, L. F. Bancsi, F. H. de Jong, A. P. Themmen, Serum anti-Mullerian hormone levels: a novel measure of ovarian reserve, Hum Reprod 17 (12) (2002) 3065-71.
[7] T. Piltonen, L. Morin-Papunen, R. Koivunen, A. Perheentupa, A. Ruokonen, J. S. Tapanainen, Serum anti-Mullerian hormone levels remain high until late reproductive age and decrease during metformin therapy in women with polycystic ovary syndrome, Hum Reprod 20 (7) (2005) 1820-6.
[8] F. Magri, L. Schena, V. Capelli, M. Gaiti, F. Zerbini, E. Brambilla, M. Rotondi, M. De Amici, A. Spinillo, R. E. Nappi, L. Chiovato, Anti-Mullerian hormone as a predictor of ovarian reserve in ART protocols: the hidden role of thyroid autoimmunity, Reprod Biol Endocrinol 13 (1) (2015) 106.
[9] B. Vollenhoven, S. Hunt, Ovarian ageing and the impact on female fertility, F1000Res 7 (2018).
[10] C. Gnoth, A. N. Schuring, K. Friol, J. Tigges, P. Mallmann, E. Godehardt, Relevance of anti-Mullerian hormone measurement in a routine IVF program, Hum Reprod 23 (6) (2008) 1359-65.
[11] Kumasawa, K., Yasui, Yuri. Nakamura, Hitomi., Kimura Tadashi. Increased Anti-mullerian Hormone (AMH) After Delivery: Case Report, Journal of Gynecology and Obstetrics 2016; 4 (3): 17-18.
[12] M. C. Inhorn, P. Patrizio, Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century, Hum Reprod Update 21 (4) (2015) 411-26.
[13] L. Bahamondes, M. Y. Makuch, Infertility care and the introduction of new reproductive technologies in poor resource settings, Reprod Biol Endocrinol 12 (2014) 87.
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Cite This Article
  • APA Style

    Nidenori Negoro, Keiichi Kumasawa, Eri Akita, Toshihiko Tomiyam a, Takeshi Taniguchi. (2021). Average and Variation of Oocyte Counts in Women Undergoing in Vitro Fertilization. Journal of Gynecology and Obstetrics, 9(2), 31-35. https://doi.org/10.11648/j.jgo.20210902.11

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    ACS Style

    Nidenori Negoro; Keiichi Kumasawa; Eri Akita; Toshihiko Tomiyam a; Takeshi Taniguchi. Average and Variation of Oocyte Counts in Women Undergoing in Vitro Fertilization. J. Gynecol. Obstet. 2021, 9(2), 31-35. doi: 10.11648/j.jgo.20210902.11

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    AMA Style

    Nidenori Negoro, Keiichi Kumasawa, Eri Akita, Toshihiko Tomiyam a, Takeshi Taniguchi. Average and Variation of Oocyte Counts in Women Undergoing in Vitro Fertilization. J Gynecol Obstet. 2021;9(2):31-35. doi: 10.11648/j.jgo.20210902.11

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  • @article{10.11648/j.jgo.20210902.11,
      author = {Nidenori Negoro and Keiichi Kumasawa and Eri Akita and Toshihiko Tomiyam a and Takeshi Taniguchi},
      title = {Average and Variation of Oocyte Counts in Women Undergoing in Vitro Fertilization},
      journal = {Journal of Gynecology and Obstetrics},
      volume = {9},
      number = {2},
      pages = {31-35},
      doi = {10.11648/j.jgo.20210902.11},
      url = {https://doi.org/10.11648/j.jgo.20210902.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20210902.11},
      abstract = {Artificial reproductive technology (ART) has become a standard treatment for patients with infertility. However the cost is burdensome to infertile patients in some countries. Moreover aging is a critical factor for infertile patients and is accompanied by higher risk of condition and counts of oocytes. In planning ART for a patient, there are two patterns of oocyte pick-up (OPU) method: One is to transfer all the embros which are obtained from one OPU. Then next OPU will be performed when she fails to get pregnant despite using up all embryos. The other method is to repeat several consecutive OPUs until sufficient stock of embryos. The sufficiency depends on age, serum AMH level, etc. This study investigates the deviation in the number of oocytes collected by OPU in infertile patients who received multiple OPU within 1 year. The number of oocytes increased as the average number of oocytes increased. However, the ratio of standard deviation/average decreased. The frequency of required OPU depends on the pregnancy rate per embryo, the background of the patient, and the number of eggs collected at the first or second OPU. Thus, the analysis will reduce their mental and economic burden. Further studies with large-scale data are needed to determine the ideal frequency of OPU.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Average and Variation of Oocyte Counts in Women Undergoing in Vitro Fertilization
    AU  - Nidenori Negoro
    AU  - Keiichi Kumasawa
    AU  - Eri Akita
    AU  - Toshihiko Tomiyam a
    AU  - Takeshi Taniguchi
    Y1  - 2021/03/04
    PY  - 2021
    N1  - https://doi.org/10.11648/j.jgo.20210902.11
    DO  - 10.11648/j.jgo.20210902.11
    T2  - Journal of Gynecology and Obstetrics
    JF  - Journal of Gynecology and Obstetrics
    JO  - Journal of Gynecology and Obstetrics
    SP  - 31
    EP  - 35
    PB  - Science Publishing Group
    SN  - 2376-7820
    UR  - https://doi.org/10.11648/j.jgo.20210902.11
    AB  - Artificial reproductive technology (ART) has become a standard treatment for patients with infertility. However the cost is burdensome to infertile patients in some countries. Moreover aging is a critical factor for infertile patients and is accompanied by higher risk of condition and counts of oocytes. In planning ART for a patient, there are two patterns of oocyte pick-up (OPU) method: One is to transfer all the embros which are obtained from one OPU. Then next OPU will be performed when she fails to get pregnant despite using up all embryos. The other method is to repeat several consecutive OPUs until sufficient stock of embryos. The sufficiency depends on age, serum AMH level, etc. This study investigates the deviation in the number of oocytes collected by OPU in infertile patients who received multiple OPU within 1 year. The number of oocytes increased as the average number of oocytes increased. However, the ratio of standard deviation/average decreased. The frequency of required OPU depends on the pregnancy rate per embryo, the background of the patient, and the number of eggs collected at the first or second OPU. Thus, the analysis will reduce their mental and economic burden. Further studies with large-scale data are needed to determine the ideal frequency of OPU.
    VL  - 9
    IS  - 2
    ER  - 

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Author Information
  • Taniguchi Hospital, Osaka, Japan

  • The Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan

  • Taniguchi Hospital, Osaka, Japan

  • Taniguchi Hospital, Osaka, Japan

  • Taniguchi Hospital, Osaka, Japan

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