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Performance of the sFLT-1 / PLGF Ratio in the Diagnosis of Preeclampsia in Four Hospitals in Brazzaville (Republic of Congo)

Received: 21 March 2022     Accepted: 7 April 2022     Published: 14 April 2022
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Abstract

Preeclampsia is a serious obstetric situation, responsible for high maternal and perinatal morbidity and mortality. Its diagnosis is clinical and biological, with confirmation either by proteinuria on the urine dipstick or by 24-hour proteinuria constituting the gold standard. Current revisions to the definition of preeclampsia tend to free themselves from reliance on proteinuria for diagnosis. They are oriented towards a broader model where the involvement of a target organ concomitant with gestational hypertension is sufficient to make the diagnosis of preeclampsia. Late positivity of proteinuria after the onset of arterial hypertension (HTA) has been reported, contrasting with the precocity of angiogenic factors such as soluble Fms tyrosine kinase type 1 (sFlt-1) and placental growth factor (PlGF). Objective. To evaluate the performance of the sFLT-1/PLGF ratio in the diagnosis of preeclampsia. Methods. Cross-sectional multicenter analytical study conducted from October 17 to December 17, 2020 including hypertensive pregnant women, treated or not, with more than 20 weeks of amenorrhea. These all benefited from the Elisa assay of sFLT-1 and PlGF after carrying out the proteinuria on the urine dipstick during the consultation. Preeclampsia was defined by the double positivity of proteinuria on the urine dipstick associated with high blood pressure (Systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg). SPSS software was used for statistical analysis and calculation of performance indices (Se; Sp; PPV; NPV; Youden “J” index, AUC). The p-value of the probability was considered significant for a value < 0.05. Results. Pregnant women were mostly multiparous with a median age of 31 years (24-35). Preeclampsia was noted in 69.2% of cases. sFLT-1 was significantly higher in preeclamptic pregnant women (409±18.9 vs 194.6±12.9; p<0.05). No significant difference was noted for PlGF (11.9 vs 13.6; p< 0.05). The sFlt-1/PlGF ratio was higher in case of preeclampsia (39.3 vs 14.6; p< 0.05). The threshold for the sFlt-/PlGF ratio retained was 18.5 (Se=86.4%; Sp=84.6%; PPV=90.5%; NPV=78.6%; J = 0.7; AUC =0.9). Conclusion. The sFlt-1/PlGF ratio was effective in the diagnosis of preeclampsia.

Published in Journal of Gynecology and Obstetrics (Volume 10, Issue 2)
DOI 10.11648/j.jgo.20221002.20
Page(s) 126-130
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Preeclampsia, sFLT-1/PLGF Ratio, Diagnostic, Brazzaville

References
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    Eouani Levy Max Emery, Buambo Gauthier Regis Jostin, Mouhingou Belmar Nick-Desy, Mokoko Jules Cesar, Potokoue Mpia Sekangue Samantha Nuelly, et al. (2022). Performance of the sFLT-1 / PLGF Ratio in the Diagnosis of Preeclampsia in Four Hospitals in Brazzaville (Republic of Congo). Journal of Gynecology and Obstetrics, 10(2), 126-130. https://doi.org/10.11648/j.jgo.20221002.20

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    ACS Style

    Eouani Levy Max Emery; Buambo Gauthier Regis Jostin; Mouhingou Belmar Nick-Desy; Mokoko Jules Cesar; Potokoue Mpia Sekangue Samantha Nuelly, et al. Performance of the sFLT-1 / PLGF Ratio in the Diagnosis of Preeclampsia in Four Hospitals in Brazzaville (Republic of Congo). J. Gynecol. Obstet. 2022, 10(2), 126-130. doi: 10.11648/j.jgo.20221002.20

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    AMA Style

    Eouani Levy Max Emery, Buambo Gauthier Regis Jostin, Mouhingou Belmar Nick-Desy, Mokoko Jules Cesar, Potokoue Mpia Sekangue Samantha Nuelly, et al. Performance of the sFLT-1 / PLGF Ratio in the Diagnosis of Preeclampsia in Four Hospitals in Brazzaville (Republic of Congo). J Gynecol Obstet. 2022;10(2):126-130. doi: 10.11648/j.jgo.20221002.20

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  • @article{10.11648/j.jgo.20221002.20,
      author = {Eouani Levy Max Emery and Buambo Gauthier Regis Jostin and Mouhingou Belmar Nick-Desy and Mokoko Jules Cesar and Potokoue Mpia Sekangue Samantha Nuelly and Itoua Clautaire and Iloki Leon Herve},
      title = {Performance of the sFLT-1 / PLGF Ratio in the Diagnosis of Preeclampsia in Four Hospitals in Brazzaville (Republic of Congo)},
      journal = {Journal of Gynecology and Obstetrics},
      volume = {10},
      number = {2},
      pages = {126-130},
      doi = {10.11648/j.jgo.20221002.20},
      url = {https://doi.org/10.11648/j.jgo.20221002.20},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20221002.20},
      abstract = {Preeclampsia is a serious obstetric situation, responsible for high maternal and perinatal morbidity and mortality. Its diagnosis is clinical and biological, with confirmation either by proteinuria on the urine dipstick or by 24-hour proteinuria constituting the gold standard. Current revisions to the definition of preeclampsia tend to free themselves from reliance on proteinuria for diagnosis. They are oriented towards a broader model where the involvement of a target organ concomitant with gestational hypertension is sufficient to make the diagnosis of preeclampsia. Late positivity of proteinuria after the onset of arterial hypertension (HTA) has been reported, contrasting with the precocity of angiogenic factors such as soluble Fms tyrosine kinase type 1 (sFlt-1) and placental growth factor (PlGF). Objective. To evaluate the performance of the sFLT-1/PLGF ratio in the diagnosis of preeclampsia. Methods. Cross-sectional multicenter analytical study conducted from October 17 to December 17, 2020 including hypertensive pregnant women, treated or not, with more than 20 weeks of amenorrhea. These all benefited from the Elisa assay of sFLT-1 and PlGF after carrying out the proteinuria on the urine dipstick during the consultation. Preeclampsia was defined by the double positivity of proteinuria on the urine dipstick associated with high blood pressure (Systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg). SPSS software was used for statistical analysis and calculation of performance indices (Se; Sp; PPV; NPV; Youden “J” index, AUC). The p-value of the probability was considered significant for a value Results. Pregnant women were mostly multiparous with a median age of 31 years (24-35). Preeclampsia was noted in 69.2% of cases. sFLT-1 was significantly higher in preeclamptic pregnant women (409±18.9 vs 194.6±12.9; pConclusion. The sFlt-1/PlGF ratio was effective in the diagnosis of preeclampsia.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Performance of the sFLT-1 / PLGF Ratio in the Diagnosis of Preeclampsia in Four Hospitals in Brazzaville (Republic of Congo)
    AU  - Eouani Levy Max Emery
    AU  - Buambo Gauthier Regis Jostin
    AU  - Mouhingou Belmar Nick-Desy
    AU  - Mokoko Jules Cesar
    AU  - Potokoue Mpia Sekangue Samantha Nuelly
    AU  - Itoua Clautaire
    AU  - Iloki Leon Herve
    Y1  - 2022/04/14
    PY  - 2022
    N1  - https://doi.org/10.11648/j.jgo.20221002.20
    DO  - 10.11648/j.jgo.20221002.20
    T2  - Journal of Gynecology and Obstetrics
    JF  - Journal of Gynecology and Obstetrics
    JO  - Journal of Gynecology and Obstetrics
    SP  - 126
    EP  - 130
    PB  - Science Publishing Group
    SN  - 2376-7820
    UR  - https://doi.org/10.11648/j.jgo.20221002.20
    AB  - Preeclampsia is a serious obstetric situation, responsible for high maternal and perinatal morbidity and mortality. Its diagnosis is clinical and biological, with confirmation either by proteinuria on the urine dipstick or by 24-hour proteinuria constituting the gold standard. Current revisions to the definition of preeclampsia tend to free themselves from reliance on proteinuria for diagnosis. They are oriented towards a broader model where the involvement of a target organ concomitant with gestational hypertension is sufficient to make the diagnosis of preeclampsia. Late positivity of proteinuria after the onset of arterial hypertension (HTA) has been reported, contrasting with the precocity of angiogenic factors such as soluble Fms tyrosine kinase type 1 (sFlt-1) and placental growth factor (PlGF). Objective. To evaluate the performance of the sFLT-1/PLGF ratio in the diagnosis of preeclampsia. Methods. Cross-sectional multicenter analytical study conducted from October 17 to December 17, 2020 including hypertensive pregnant women, treated or not, with more than 20 weeks of amenorrhea. These all benefited from the Elisa assay of sFLT-1 and PlGF after carrying out the proteinuria on the urine dipstick during the consultation. Preeclampsia was defined by the double positivity of proteinuria on the urine dipstick associated with high blood pressure (Systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg). SPSS software was used for statistical analysis and calculation of performance indices (Se; Sp; PPV; NPV; Youden “J” index, AUC). The p-value of the probability was considered significant for a value Results. Pregnant women were mostly multiparous with a median age of 31 years (24-35). Preeclampsia was noted in 69.2% of cases. sFLT-1 was significantly higher in preeclamptic pregnant women (409±18.9 vs 194.6±12.9; pConclusion. The sFlt-1/PlGF ratio was effective in the diagnosis of preeclampsia.
    VL  - 10
    IS  - 2
    ER  - 

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Author Information
  • Obstetrics Gynecology Department, Loandjili General Hospital, Pointe Noire, Congo

  • Obstetrics Gynecology Department, University Hospital Center of Brazzaville, Brazzaville, Congo

  • Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Congo

  • Obstetrics Gynecology Department, University Hospital Center of Brazzaville, Brazzaville, Congo

  • Obstetrics Gynecology Department, University Hospital Center of Brazzaville, Brazzaville, Congo

  • Obstetrics Gynecology Department, University Hospital Center of Brazzaville, Brazzaville, Congo

  • Obstetrics Gynecology Department, University Hospital Center of Brazzaville, Brazzaville, Congo

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