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A Case of Very Severe Anemia in Pregnancy Combined with Beta-Thalassemia Major and Pre-Eclampsia

Received: 5 March 2023     Accepted: 30 March 2023     Published: 11 April 2023
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Abstract

OBJECTIVE: To investigate the clinical diagnosis, preventive antenatal screening and antenatal diagnosis, pregnancy management, timing and mode of delivery and postnatal management of β-thalassaemia in pregnancy combined. METHODS: Retrospective analysis of the medical history and treatment of a patient with β-thalassaemia in pregnancy combined with pregnancy outcome. RESULTS: The patient recovered well, had a normal temperature, the abdominal incision was removed at 7 d, the II/nail healed, the general obstetric condition was acceptable and she was discharged successfully. CONCLUSION: Anaemia is very common in pregnancy, but very severe anaemia in pregnancy is extremely rare and it is important to define the cause of anaemia. Thalassaemia is a group of inherited chronic haemolytic disorders caused by autosomal defects, which can be aggravated by pregnancy. Thalassaemia can be divided into α-, β-, γ-, δ-, δβ- and other categories, and for β-thalassaemia it can be divided into mild, moderate and severe, with both intermediate and severe patients presenting early with obvious anaemic symptoms and relying on long-term transfusion therapy. The majority of these patients die in childhood and are extremely rare in pregnancy. Thalassaemia in pregnancy can directly affect the outcome of pregnancy and cause many near and long-term complications in the newborn, and timely antenatal screening and prenatal diagnosis can detect the disease early. Active obstetric management and timing of pregnancy can also help to improve maternal and infant pregnancy outcomes.

Published in Journal of Gynecology and Obstetrics (Volume 11, Issue 2)
DOI 10.11648/j.jgo.20231102.12
Page(s) 36-40
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Pregnancy, Beta-Thalassemia, Very Severe Anaemia, Pre-eclampsia

References
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[2] LU Xin, KAN Shifeng. Significance of irregular antibody screening in pregnant women and normal female blood recipients in clinically safe blood transfusion [J]. Progress in Modern Obstetrics and Gynecology, 2009, 18 (09): 718-719.
[3] Nair M, Choudhury M K, Choudhury S S, et al. Association between maternal anaemia and pregnancy outcomes: A cohort study in assam, india [J]. BMJ Glob Health, 2016, 1 (1): e000026.
[4] Suryanarayana R, Chandrappa M, Santhuram A N, et al. Prospective study on prevalence of anemia of pregnant women and its outcome: A community based study [J]. J Family Med Prim Care, 2017, 6 (4): 739-743.
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[16] Hypertension Disorders Group of Pregnancy of Obstetrics and Gynecology Branch of Chinese Medical Association. Guidelines for the diagnosis and treatment of hypertension during pregnancy (2020) [J]. Chinese Journal of Obstetrics and Gynecology, 2020, 55 (04): 227-238.
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  • APA Style

    Xuan Gong, Xiaomin Xiao. (2023). A Case of Very Severe Anemia in Pregnancy Combined with Beta-Thalassemia Major and Pre-Eclampsia. Journal of Gynecology and Obstetrics, 11(2), 36-40. https://doi.org/10.11648/j.jgo.20231102.12

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    ACS Style

    Xuan Gong; Xiaomin Xiao. A Case of Very Severe Anemia in Pregnancy Combined with Beta-Thalassemia Major and Pre-Eclampsia. J. Gynecol. Obstet. 2023, 11(2), 36-40. doi: 10.11648/j.jgo.20231102.12

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    AMA Style

    Xuan Gong, Xiaomin Xiao. A Case of Very Severe Anemia in Pregnancy Combined with Beta-Thalassemia Major and Pre-Eclampsia. J Gynecol Obstet. 2023;11(2):36-40. doi: 10.11648/j.jgo.20231102.12

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  • @article{10.11648/j.jgo.20231102.12,
      author = {Xuan Gong and Xiaomin Xiao},
      title = {A Case of Very Severe Anemia in Pregnancy Combined with Beta-Thalassemia Major and Pre-Eclampsia},
      journal = {Journal of Gynecology and Obstetrics},
      volume = {11},
      number = {2},
      pages = {36-40},
      doi = {10.11648/j.jgo.20231102.12},
      url = {https://doi.org/10.11648/j.jgo.20231102.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20231102.12},
      abstract = {OBJECTIVE: To investigate the clinical diagnosis, preventive antenatal screening and antenatal diagnosis, pregnancy management, timing and mode of delivery and postnatal management of β-thalassaemia in pregnancy combined. METHODS: Retrospective analysis of the medical history and treatment of a patient with β-thalassaemia in pregnancy combined with pregnancy outcome. RESULTS: The patient recovered well, had a normal temperature, the abdominal incision was removed at 7 d, the II/nail healed, the general obstetric condition was acceptable and she was discharged successfully. CONCLUSION: Anaemia is very common in pregnancy, but very severe anaemia in pregnancy is extremely rare and it is important to define the cause of anaemia. Thalassaemia is a group of inherited chronic haemolytic disorders caused by autosomal defects, which can be aggravated by pregnancy. Thalassaemia can be divided into α-, β-, γ-, δ-, δβ- and other categories, and for β-thalassaemia it can be divided into mild, moderate and severe, with both intermediate and severe patients presenting early with obvious anaemic symptoms and relying on long-term transfusion therapy. The majority of these patients die in childhood and are extremely rare in pregnancy. Thalassaemia in pregnancy can directly affect the outcome of pregnancy and cause many near and long-term complications in the newborn, and timely antenatal screening and prenatal diagnosis can detect the disease early. Active obstetric management and timing of pregnancy can also help to improve maternal and infant pregnancy outcomes.},
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - A Case of Very Severe Anemia in Pregnancy Combined with Beta-Thalassemia Major and Pre-Eclampsia
    AU  - Xuan Gong
    AU  - Xiaomin Xiao
    Y1  - 2023/04/11
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    N1  - https://doi.org/10.11648/j.jgo.20231102.12
    DO  - 10.11648/j.jgo.20231102.12
    T2  - Journal of Gynecology and Obstetrics
    JF  - Journal of Gynecology and Obstetrics
    JO  - Journal of Gynecology and Obstetrics
    SP  - 36
    EP  - 40
    PB  - Science Publishing Group
    SN  - 2376-7820
    UR  - https://doi.org/10.11648/j.jgo.20231102.12
    AB  - OBJECTIVE: To investigate the clinical diagnosis, preventive antenatal screening and antenatal diagnosis, pregnancy management, timing and mode of delivery and postnatal management of β-thalassaemia in pregnancy combined. METHODS: Retrospective analysis of the medical history and treatment of a patient with β-thalassaemia in pregnancy combined with pregnancy outcome. RESULTS: The patient recovered well, had a normal temperature, the abdominal incision was removed at 7 d, the II/nail healed, the general obstetric condition was acceptable and she was discharged successfully. CONCLUSION: Anaemia is very common in pregnancy, but very severe anaemia in pregnancy is extremely rare and it is important to define the cause of anaemia. Thalassaemia is a group of inherited chronic haemolytic disorders caused by autosomal defects, which can be aggravated by pregnancy. Thalassaemia can be divided into α-, β-, γ-, δ-, δβ- and other categories, and for β-thalassaemia it can be divided into mild, moderate and severe, with both intermediate and severe patients presenting early with obvious anaemic symptoms and relying on long-term transfusion therapy. The majority of these patients die in childhood and are extremely rare in pregnancy. Thalassaemia in pregnancy can directly affect the outcome of pregnancy and cause many near and long-term complications in the newborn, and timely antenatal screening and prenatal diagnosis can detect the disease early. Active obstetric management and timing of pregnancy can also help to improve maternal and infant pregnancy outcomes.
    VL  - 11
    IS  - 2
    ER  - 

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Author Information
  • First School of Clinical Medicine, Jinan University, Guangzhou, China

  • First School of Clinical Medicine, Jinan University, Guangzhou, China

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