Relationship Between Serum Copper, Zinc Level and Tumour Aggressiveness in Invasive Cervical Cancer

Naznine Akter; Syfun Naher; Mahfuza Akhter; Mahbuba Akhter Jahan; Jannatul Islam; Sunzia Sayed; Raihana Islam; Muhammad Zakaria Rana

doi:doi:10.11648/j.jgo.20241205.11

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Relationship Between Serum Copper, Zinc Level and Tumour Aggressiveness in Invasive Cervical Cancer

Naznine Akter^*

, Syfun Naher

, Mahfuza Akhter

, Mahbuba Akhter Jahan

, Jannatul Islam

, Sunzia Sayed

, Raihana Islam

, Muhammad Zakaria Rana

Published in Journal of Gynecology and Obstetrics (Volume 12, Issue 5)

Received: 20 August 2024 Accepted: 5 September 2024 Published: 23 September 2024

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Abstract

Background: Cervical cancer, a leading cause of cancer-related morbidity and mortality, exhibits considerable variability in aggressiveness. The role of trace elements such as copper and zinc in influencing tumor behavior and progression has garnered attention. This study investigates the relationship between serum copper and zinc levels and tumor aggressiveness in invasive cervical cancer. Methods: A cross-sectional comparative study was conducted among 150 women with invasive cervical cancer attending the outpatient department and Colposcopy Clinic of the Department of Gynecological Oncology, BSMMU, Dhaka, from April 2022 to March 2023. Participants were divided into two groups based on tumor aggressiveness: Group 1 (less aggressive) and Group 2 (more aggressive), with 75 women in each group. Serum copper and zinc levels were measured and analyzed for differences between groups. Result: Serum copper levels were significantly higher in Group 2 (152.31 ± 41.81 µg/dL) compared to Group 1 (139.31 ± 25.52 µg/dL) with a p-value of 0.023. Conversely, serum zinc levels were significantly lower in Group 2 (55.24 ± 28.13 µg/dL) compared to Group 1 (66.29 ± 31.58 µg/dL) with a p-value of 0.025. The copper/zinc ratio was significantly higher in Group 2 (2.76 ± 1.20) compared to Group 1 (2.10 ± 1.00) with a p-value of <0.001. Conclusion: Elevated serum copper levels and copper/zinc ratio, along with decreased zinc levels, are associated with more aggressive cervical cancer. These findings suggest that trace element imbalances may serve as biomarkers for assessing tumor aggressiveness and could inform future therapeutic strategies.

Published in	Journal of Gynecology and Obstetrics (Volume 12, Issue 5)
DOI	10.11648/j.jgo.20241205.11
Page(s)	90-95
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Cervical Cancer, Copper, Zinc, Tumor Aggressiveness, Biomarker

References

[1]	Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018; 68(6): 394-424. https://doi.org/10.3322/caac.21492
[2]	Kim BE, Nevitt T, Thiele DJ. Mechanisms for copper acquisition, distribution and regulation. Nat Chem Biol. 2008; 4(3): 176-85. https://doi.org/10.1038/nchembio.60
[3]	Li Y, Jiang Y, Zhang C, Xu J, Zuo Y, Li Y. Copper and copper homeostasis in cancer. Cancer Lett. 2019; 454: 176-82. https://doi.org/10.1016/j.canlet.2019.02.007
[4]	Prasad AS. Zinc is an antioxidant and anti-inflammatory agent: its role in human health. Front Nutr. 2021; 8: 660411. https://doi.org/10.3389/fnut.2021.660411
[5]	Kim BW, Lee J, Ko S, Kim H, Lee HJ, Kim H, et al. Zinc deficiency and its impact on cancer progression. Biol Trace Elem Res. 2020; 195(2): 405-12. https://doi.org/10.1007/s12011-019-01945-2
[6]	Sinha S, Patil N, Bharne A, Bhawani M, Ingle A. Copper/zinc imbalance and cancer. BioMetals. 2019; 32(3): 327-41. https://doi.org/10.1007/s10534-019-00188-3
[7]	Shi Y, Sun W, Wang W, Tang J, Wang J. The role of copper and zinc in cancer: a review of epidemiological studies. Sci Rep. 2021; 11(1): 14278. https://doi.org/10.1038/s41598-021-93698-7
[8]	Nagy ZS, Szigeti A, Juhasz L, Palinkas L, Toth J, Darnel A. Serum copper and zinc levels and their relationship with cancer progression in cervical cancer patients. Oncol Lett. 2018; 16(6): 7212-20. https://doi.org/10.3892/ol.2018.9636
[9]	Liu Y, Xu J, Chen M, Huang Y, Zhou Y, Liu J, et al. Serum trace elements and their association with the progression of cervical cancer. Biol Trace Elem Res. 2022; 200(1): 118-26. https://doi.org/10.1007/s12011-021-02808-7
[10]	Singh S, Patel R, Singh S. Role of trace elements in cervical cancer progression. J Cancer Res Ther. 2019; 15(4): 786-92. https://doi.org/10.4103/jcrt.JCRT_751_18
[11]	Velázquez J, Gaviño M, González F, Martínez F, Rodríguez S, Ortega E. Trace elements in cancer diagnosis and prognosis: copper and zinc in cervical cancer. Clin Chim Acta. 2017; 467: 126-31. https://doi.org/10.1016/j.cca.2017.02.009
[12]	Yang Q, Liu T, Liu Z, Liu X, Wang X. The effects of copper and zinc on cervical cancer cells: A review. J Biol Inorg Chem. 2020; 25(7): 1009-21. https://doi.org/10.1007/s00775-020-01715-1
[13]	Micozzi MS, Franke A, Etzel C. Copper, zinc, and cancer risk: A review of epidemiological studies. Cancer Causes Control. 2018; 29(5): 511-24. https://doi.org/10.1007/s10552-018-1027-2
[14]	Zeng H, Tan H, Li X, Liu X. Copper and zinc imbalance and its association with cervical cancer progression. J Trace Elem Med Biol. 2021; 67: 102814. https://doi.org/10.1016/j.jtemb.2021.102814
[15]	Kuo YM, Sdrues M, Gibb D, et al. Serum copper and zinc levels in cancer patients: a review. Nutr Cancer. 2018; 70(5): 709-21. https://doi.org/10.1080/01635581.2018.1466739
[16]	Yucel I, Arslan C, Bakar B, et al. Serum copper and zinc levels in patients with uterine cervical cancer. Biol Trace Elem Res. 2016; 171(2): 245-252.
[17]	Varghese S, Pandey M, Bhagat R, et al. Serum copper and zinc levels in patients with cervical cancer. Indian J Med Paediatr Oncol. 2015; 36(2): 113-117.
[18]	Kanthasamy A, Balakrishnan V, Natarajan S, et al. Copper/zinc ratio as a predictive marker for cervical cancer progression. Cancer Epidemiol. 2018; 56: 127-134.
[19]	Goodman VL, Brewer GJ, Merajver SD. Copper deficiency as an anti-cancer strategy. Endocr Relat Cancer. 2004; 11(2): 255-263.
[20]	Tisato F, Marzano C, Porchia M, et al. Copper in diseases and treatments, and copper-based anticancer strategies. Med Res Rev. 2010; 30(4): 708-749.
[21]	Costello LC, Franklin RB. The clinical relevance of the metabolism of zinc in the prevention and treatment of prostate cancer: an update. Integr Cancer Ther. 2014; 13(3): 196-209.
[22]	Singh P, Jain M, Srivastava S, et al. Serum trace elements and risk of cervical cancer: A case-control study in Indian population. J Obstet Gynaecol India. 2019; 69(1): 36-41.
[23]	Liu M, Zhang H, Guo X, et al. Copper transporter ATP7B upregulation promotes cervical cancer progression through the PI3K/AKT pathway. Oncol Lett. 2020; 19(4): 2985-2991.
[24]	Prasad AS, Bao B, Beck FW, et al. Zinc supplementation decreases oxidative stress, incidence of infection, and generation of inflammatory cytokines in elderly subjects. Mol Nutr Food Res. 2018; 62(10): 1700831.

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APA Style

Akter, N., Naher, S., Akhter, M., Jahan, M. A., Islam, J., et al. (2024). Relationship Between Serum Copper, Zinc Level and Tumour Aggressiveness in Invasive Cervical Cancer. Journal of Gynecology and Obstetrics, 12(5), 90-95. https://doi.org/10.11648/j.jgo.20241205.11

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ACS Style

Akter, N.; Naher, S.; Akhter, M.; Jahan, M. A.; Islam, J., et al. Relationship Between Serum Copper, Zinc Level and Tumour Aggressiveness in Invasive Cervical Cancer. J. Gynecol. Obstet. 2024, 12(5), 90-95. doi: 10.11648/j.jgo.20241205.11

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AMA Style

Akter N, Naher S, Akhter M, Jahan MA, Islam J, et al. Relationship Between Serum Copper, Zinc Level and Tumour Aggressiveness in Invasive Cervical Cancer. J Gynecol Obstet. 2024;12(5):90-95. doi: 10.11648/j.jgo.20241205.11

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@article{10.11648/j.jgo.20241205.11,
  author = {Naznine Akter and Syfun Naher and Mahfuza Akhter and Mahbuba Akhter Jahan and Jannatul Islam and Sunzia Sayed and Raihana Islam and Muhammad Zakaria Rana},
  title = {Relationship Between Serum Copper, Zinc Level and Tumour Aggressiveness in Invasive Cervical Cancer
},
  journal = {Journal of Gynecology and Obstetrics},
  volume = {12},
  number = {5},
  pages = {90-95},
  doi = {10.11648/j.jgo.20241205.11},
  url = {https://doi.org/10.11648/j.jgo.20241205.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20241205.11},
  abstract = {Background: Cervical cancer, a leading cause of cancer-related morbidity and mortality, exhibits considerable variability in aggressiveness. The role of trace elements such as copper and zinc in influencing tumor behavior and progression has garnered attention. This study investigates the relationship between serum copper and zinc levels and tumor aggressiveness in invasive cervical cancer. Methods: A cross-sectional comparative study was conducted among 150 women with invasive cervical cancer attending the outpatient department and Colposcopy Clinic of the Department of Gynecological Oncology, BSMMU, Dhaka, from April 2022 to March 2023. Participants were divided into two groups based on tumor aggressiveness: Group 1 (less aggressive) and Group 2 (more aggressive), with 75 women in each group. Serum copper and zinc levels were measured and analyzed for differences between groups. Result: Serum copper levels were significantly higher in Group 2 (152.31 ± 41.81 µg/dL) compared to Group 1 (139.31 ± 25.52 µg/dL) with a p-value of 0.023. Conversely, serum zinc levels were significantly lower in Group 2 (55.24 ± 28.13 µg/dL) compared to Group 1 (66.29 ± 31.58 µg/dL) with a p-value of 0.025. The copper/zinc ratio was significantly higher in Group 2 (2.76 ± 1.20) compared to Group 1 (2.10 ± 1.00) with a p-value of Conclusion: Elevated serum copper levels and copper/zinc ratio, along with decreased zinc levels, are associated with more aggressive cervical cancer. These findings suggest that trace element imbalances may serve as biomarkers for assessing tumor aggressiveness and could inform future therapeutic strategies.
},
 year = {2024}
}

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TY  - JOUR
T1  - Relationship Between Serum Copper, Zinc Level and Tumour Aggressiveness in Invasive Cervical Cancer

AU  - Naznine Akter
AU  - Syfun Naher
AU  - Mahfuza Akhter
AU  - Mahbuba Akhter Jahan
AU  - Jannatul Islam
AU  - Sunzia Sayed
AU  - Raihana Islam
AU  - Muhammad Zakaria Rana
Y1  - 2024/09/23
PY  - 2024
N1  - https://doi.org/10.11648/j.jgo.20241205.11
DO  - 10.11648/j.jgo.20241205.11
T2  - Journal of Gynecology and Obstetrics
JF  - Journal of Gynecology and Obstetrics
JO  - Journal of Gynecology and Obstetrics
SP  - 90
EP  - 95
PB  - Science Publishing Group
SN  - 2376-7820
UR  - https://doi.org/10.11648/j.jgo.20241205.11
AB  - Background: Cervical cancer, a leading cause of cancer-related morbidity and mortality, exhibits considerable variability in aggressiveness. The role of trace elements such as copper and zinc in influencing tumor behavior and progression has garnered attention. This study investigates the relationship between serum copper and zinc levels and tumor aggressiveness in invasive cervical cancer. Methods: A cross-sectional comparative study was conducted among 150 women with invasive cervical cancer attending the outpatient department and Colposcopy Clinic of the Department of Gynecological Oncology, BSMMU, Dhaka, from April 2022 to March 2023. Participants were divided into two groups based on tumor aggressiveness: Group 1 (less aggressive) and Group 2 (more aggressive), with 75 women in each group. Serum copper and zinc levels were measured and analyzed for differences between groups. Result: Serum copper levels were significantly higher in Group 2 (152.31 ± 41.81 µg/dL) compared to Group 1 (139.31 ± 25.52 µg/dL) with a p-value of 0.023. Conversely, serum zinc levels were significantly lower in Group 2 (55.24 ± 28.13 µg/dL) compared to Group 1 (66.29 ± 31.58 µg/dL) with a p-value of 0.025. The copper/zinc ratio was significantly higher in Group 2 (2.76 ± 1.20) compared to Group 1 (2.10 ± 1.00) with a p-value of Conclusion: Elevated serum copper levels and copper/zinc ratio, along with decreased zinc levels, are associated with more aggressive cervical cancer. These findings suggest that trace element imbalances may serve as biomarkers for assessing tumor aggressiveness and could inform future therapeutic strategies.

VL  - 12
IS  - 5
ER  -

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Author Information

Naznine Akter

Directorate General of Health Services, Dhaka, Bangladesh

Contact Email

http://orcid.org/0009-0000-9927-4121
Syfun Naher

Directorate General of Health Services, Dhaka, Bangladesh

Contact Email

http://orcid.org/0009-0003-5523-1965
Mahfuza Akhter

Department of Obstetrics and Gynecology, Mugda Medical College Hospital, Dhaka, Bangladesh

Contact Email

http://orcid.org/0009-0002-8549-1445
Mahbuba Akhter Jahan

Department of Obstetrics and Gynecology, Shaheed Tajuddin Ahmad Medical College Hospital, Gazipur, Bangladesh

Contact Email

http://orcid.org/0009-0002-4133-2493
Jannatul Islam

Upazilla Health Complex, Cumilla, Bangladesh

Contact Email

http://orcid.org/0009-0008-3957-0277
Sunzia Sayed

Department of Gynecological Oncology, Bangabandu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh

Contact Email

http://orcid.org/0009-0009-6645-5474
Raihana Islam

Department of Medicine, BIRDEM General Hospital, Dhaka, Bangladesh

Contact Email

http://orcid.org/0009-0008-4316-6621
Muhammad Zakaria Rana

Directorate General of Health Services, Dhaka, Bangladesh

Contact Email

http://orcid.org/0009-0003-4440-8964

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Plain Text BibTeX RIS

APA Style

Akter, N., Naher, S., Akhter, M., Jahan, M. A., Islam, J., et al. (2024). Relationship Between Serum Copper, Zinc Level and Tumour Aggressiveness in Invasive Cervical Cancer. Journal of Gynecology and Obstetrics, 12(5), 90-95. https://doi.org/10.11648/j.jgo.20241205.11

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ACS Style

Akter, N.; Naher, S.; Akhter, M.; Jahan, M. A.; Islam, J., et al. Relationship Between Serum Copper, Zinc Level and Tumour Aggressiveness in Invasive Cervical Cancer. J. Gynecol. Obstet. 2024, 12(5), 90-95. doi: 10.11648/j.jgo.20241205.11

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AMA Style

Akter N, Naher S, Akhter M, Jahan MA, Islam J, et al. Relationship Between Serum Copper, Zinc Level and Tumour Aggressiveness in Invasive Cervical Cancer. J Gynecol Obstet. 2024;12(5):90-95. doi: 10.11648/j.jgo.20241205.11

Copy | Download

@article{10.11648/j.jgo.20241205.11,
  author = {Naznine Akter and Syfun Naher and Mahfuza Akhter and Mahbuba Akhter Jahan and Jannatul Islam and Sunzia Sayed and Raihana Islam and Muhammad Zakaria Rana},
  title = {Relationship Between Serum Copper, Zinc Level and Tumour Aggressiveness in Invasive Cervical Cancer
},
  journal = {Journal of Gynecology and Obstetrics},
  volume = {12},
  number = {5},
  pages = {90-95},
  doi = {10.11648/j.jgo.20241205.11},
  url = {https://doi.org/10.11648/j.jgo.20241205.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20241205.11},
  abstract = {Background: Cervical cancer, a leading cause of cancer-related morbidity and mortality, exhibits considerable variability in aggressiveness. The role of trace elements such as copper and zinc in influencing tumor behavior and progression has garnered attention. This study investigates the relationship between serum copper and zinc levels and tumor aggressiveness in invasive cervical cancer. Methods: A cross-sectional comparative study was conducted among 150 women with invasive cervical cancer attending the outpatient department and Colposcopy Clinic of the Department of Gynecological Oncology, BSMMU, Dhaka, from April 2022 to March 2023. Participants were divided into two groups based on tumor aggressiveness: Group 1 (less aggressive) and Group 2 (more aggressive), with 75 women in each group. Serum copper and zinc levels were measured and analyzed for differences between groups. Result: Serum copper levels were significantly higher in Group 2 (152.31 ± 41.81 µg/dL) compared to Group 1 (139.31 ± 25.52 µg/dL) with a p-value of 0.023. Conversely, serum zinc levels were significantly lower in Group 2 (55.24 ± 28.13 µg/dL) compared to Group 1 (66.29 ± 31.58 µg/dL) with a p-value of 0.025. The copper/zinc ratio was significantly higher in Group 2 (2.76 ± 1.20) compared to Group 1 (2.10 ± 1.00) with a p-value of Conclusion: Elevated serum copper levels and copper/zinc ratio, along with decreased zinc levels, are associated with more aggressive cervical cancer. These findings suggest that trace element imbalances may serve as biomarkers for assessing tumor aggressiveness and could inform future therapeutic strategies.
},
 year = {2024}
}

Copy | Download

TY  - JOUR
T1  - Relationship Between Serum Copper, Zinc Level and Tumour Aggressiveness in Invasive Cervical Cancer

AU  - Naznine Akter
AU  - Syfun Naher
AU  - Mahfuza Akhter
AU  - Mahbuba Akhter Jahan
AU  - Jannatul Islam
AU  - Sunzia Sayed
AU  - Raihana Islam
AU  - Muhammad Zakaria Rana
Y1  - 2024/09/23
PY  - 2024
N1  - https://doi.org/10.11648/j.jgo.20241205.11
DO  - 10.11648/j.jgo.20241205.11
T2  - Journal of Gynecology and Obstetrics
JF  - Journal of Gynecology and Obstetrics
JO  - Journal of Gynecology and Obstetrics
SP  - 90
EP  - 95
PB  - Science Publishing Group
SN  - 2376-7820
UR  - https://doi.org/10.11648/j.jgo.20241205.11
AB  - Background: Cervical cancer, a leading cause of cancer-related morbidity and mortality, exhibits considerable variability in aggressiveness. The role of trace elements such as copper and zinc in influencing tumor behavior and progression has garnered attention. This study investigates the relationship between serum copper and zinc levels and tumor aggressiveness in invasive cervical cancer. Methods: A cross-sectional comparative study was conducted among 150 women with invasive cervical cancer attending the outpatient department and Colposcopy Clinic of the Department of Gynecological Oncology, BSMMU, Dhaka, from April 2022 to March 2023. Participants were divided into two groups based on tumor aggressiveness: Group 1 (less aggressive) and Group 2 (more aggressive), with 75 women in each group. Serum copper and zinc levels were measured and analyzed for differences between groups. Result: Serum copper levels were significantly higher in Group 2 (152.31 ± 41.81 µg/dL) compared to Group 1 (139.31 ± 25.52 µg/dL) with a p-value of 0.023. Conversely, serum zinc levels were significantly lower in Group 2 (55.24 ± 28.13 µg/dL) compared to Group 1 (66.29 ± 31.58 µg/dL) with a p-value of 0.025. The copper/zinc ratio was significantly higher in Group 2 (2.76 ± 1.20) compared to Group 1 (2.10 ± 1.00) with a p-value of Conclusion: Elevated serum copper levels and copper/zinc ratio, along with decreased zinc levels, are associated with more aggressive cervical cancer. These findings suggest that trace element imbalances may serve as biomarkers for assessing tumor aggressiveness and could inform future therapeutic strategies.

VL  - 12
IS  - 5
ER  -

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