Study on the Changes of Antibody IgM and IgG Based on the Plasma Treatment of COVID-19 in Patients with New Coronary Pneumonia

Duan Li; Qin Ying; Li Yuanda; Zhang Chi; Qu Xiaojuan; Wang Zifan; Baishan•Hunapiya; Wang Fan; Lin Zhiqiang; Lin Guoyue

doi:doi:10.11648/j.sd.20221001.11

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Study on the Changes of Antibody IgM and IgG Based on the Plasma Treatment of COVID-19 in Patients with New Coronary Pneumonia

Duan Li, Qin Ying, Li Yuanda, Zhang Chi, Qu Xiaojuan, Wang Zifan, Baishan•Hunapiya, Wang Fan, Lin Zhiqiang, Lin Guoyue

Published in Science Discovery (Volume 10, Issue 1)

Received: 7 January 2022 Published: 8 January 2022

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Abstract

Objective To apply the convalescent plasma of recovered patients with new coronary pneumonia to treat COVID-19 to explore the changes of antibodies IgM and IgG in their bodies and the therapeutic effect. Methods Plasma treatment was performed for COVID-19, and the values of antibody IgM and IgG ct were observed and statistically analyzed. Results (1) 99 cases of rapid development, severe and critically ill patients were transfused with 107250ml plasma, 1083.33ml per capita. The effective rate of blood transfusion was 100% and the cure rate was 100%. (2) The 229 bags of convalescent plasma of the infused convalescent patients have an IgG ct value of 31.61±23.28 and an IgM of 7.19±11.94. (3) The antibody IgG and IgM ct values (68.70±69.14 and 47.89±64.63) of patients in the blood transfusion group were higher than the pre-transfusion ct values (4.46±13.99 and 4.46±13.99), and the differences were significant (p<0.05); The antibody IgM and IgG ct values at discharge of the non-transfusion group were higher than the antibody ct values at admission (p<0.05); in general, the IgM and IgG antibody ct values of the blood transfusion group were 1-3 times higher than those of the non-transfusion group, and there was no difference ( p>0.05), but the levels of antibody IgG and IgM in severe patients in the blood transfusion group were significantly higher than those in the non-transfusion group (P<0.05). (4) The hospitalization days of the fast-growing and severe patients in the blood transfusion group were significantly shorter than those in the non-transfusion group (P<0.05). Conclusion The application of convalescent plasma from patients recovering from new coronary pneumonia to treat COVID-19 can greatly increase the antibody content in severe and critically ill patients, effectively enhance immune function, shorten the length of hospital stay, and speed up the early improvement of the disease.

Published in	Science Discovery (Volume 10, Issue 1)
DOI	10.11648/j.sd.20221001.11
Page(s)	1-6
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Novel Coronavirus, New Coronary Pneumonia, Recovered Plasma, Treatment, Antibody/IgM/IgG

References

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APA Style

Duan Li, Qin Ying, Li Yuanda, Zhang Chi, Qu Xiaojuan, et al. (2022). Study on the Changes of Antibody IgM and IgG Based on the Plasma Treatment of COVID-19 in Patients with New Coronary Pneumonia. Science Discovery, 10(1), 1-6. https://doi.org/10.11648/j.sd.20221001.11

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ACS Style

Duan Li; Qin Ying; Li Yuanda; Zhang Chi; Qu Xiaojuan, et al. Study on the Changes of Antibody IgM and IgG Based on the Plasma Treatment of COVID-19 in Patients with New Coronary Pneumonia. Sci. Discov. 2022, 10(1), 1-6. doi: 10.11648/j.sd.20221001.11

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AMA Style

Duan Li, Qin Ying, Li Yuanda, Zhang Chi, Qu Xiaojuan, et al. Study on the Changes of Antibody IgM and IgG Based on the Plasma Treatment of COVID-19 in Patients with New Coronary Pneumonia. Sci Discov. 2022;10(1):1-6. doi: 10.11648/j.sd.20221001.11

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@article{10.11648/j.sd.20221001.11,
  author = {Duan Li and Qin Ying and Li Yuanda and Zhang Chi and Qu Xiaojuan and Wang Zifan and Baishan•Hunapiya and Wang Fan and Lin Zhiqiang and Lin Guoyue},
  title = {Study on the Changes of Antibody IgM and IgG Based on the Plasma Treatment of COVID-19 in Patients with New Coronary Pneumonia},
  journal = {Science Discovery},
  volume = {10},
  number = {1},
  pages = {1-6},
  doi = {10.11648/j.sd.20221001.11},
  url = {https://doi.org/10.11648/j.sd.20221001.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20221001.11},
  abstract = {Objective To apply the convalescent plasma of recovered patients with new coronary pneumonia to treat COVID-19 to explore the changes of antibodies IgM and IgG in their bodies and the therapeutic effect. Methods Plasma treatment was performed for COVID-19, and the values of antibody IgM and IgG ct were observed and statistically analyzed. Results (1) 99 cases of rapid development, severe and critically ill patients were transfused with 107250ml plasma, 1083.33ml per capita. The effective rate of blood transfusion was 100% and the cure rate was 100%. (2) The 229 bags of convalescent plasma of the infused convalescent patients have an IgG ct value of 31.61±23.28 and an IgM of 7.19±11.94. (3) The antibody IgG and IgM ct values (68.70±69.14 and 47.89±64.63) of patients in the blood transfusion group were higher than the pre-transfusion ct values (4.46±13.99 and 4.46±13.99), and the differences were significant (p0.05), but the levels of antibody IgG and IgM in severe patients in the blood transfusion group were significantly higher than those in the non-transfusion group (P<0.05). (4) The hospitalization days of the fast-growing and severe patients in the blood transfusion group were significantly shorter than those in the non-transfusion group (P<0.05). Conclusion The application of convalescent plasma from patients recovering from new coronary pneumonia to treat COVID-19 can greatly increase the antibody content in severe and critically ill patients, effectively enhance immune function, shorten the length of hospital stay, and speed up the early improvement of the disease.},
 year = {2022}
}

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TY  - JOUR
T1  - Study on the Changes of Antibody IgM and IgG Based on the Plasma Treatment of COVID-19 in Patients with New Coronary Pneumonia
AU  - Duan Li
AU  - Qin Ying
AU  - Li Yuanda
AU  - Zhang Chi
AU  - Qu Xiaojuan
AU  - Wang Zifan
AU  - Baishan•Hunapiya
AU  - Wang Fan
AU  - Lin Zhiqiang
AU  - Lin Guoyue
Y1  - 2022/01/08
PY  - 2022
N1  - https://doi.org/10.11648/j.sd.20221001.11
DO  - 10.11648/j.sd.20221001.11
T2  - Science Discovery
JF  - Science Discovery
JO  - Science Discovery
SP  - 1
EP  - 6
PB  - Science Publishing Group
SN  - 2331-0650
UR  - https://doi.org/10.11648/j.sd.20221001.11
AB  - Objective To apply the convalescent plasma of recovered patients with new coronary pneumonia to treat COVID-19 to explore the changes of antibodies IgM and IgG in their bodies and the therapeutic effect. Methods Plasma treatment was performed for COVID-19, and the values of antibody IgM and IgG ct were observed and statistically analyzed. Results (1) 99 cases of rapid development, severe and critically ill patients were transfused with 107250ml plasma, 1083.33ml per capita. The effective rate of blood transfusion was 100% and the cure rate was 100%. (2) The 229 bags of convalescent plasma of the infused convalescent patients have an IgG ct value of 31.61±23.28 and an IgM of 7.19±11.94. (3) The antibody IgG and IgM ct values (68.70±69.14 and 47.89±64.63) of patients in the blood transfusion group were higher than the pre-transfusion ct values (4.46±13.99 and 4.46±13.99), and the differences were significant (p0.05), but the levels of antibody IgG and IgM in severe patients in the blood transfusion group were significantly higher than those in the non-transfusion group (P<0.05). (4) The hospitalization days of the fast-growing and severe patients in the blood transfusion group were significantly shorter than those in the non-transfusion group (P<0.05). Conclusion The application of convalescent plasma from patients recovering from new coronary pneumonia to treat COVID-19 can greatly increase the antibody content in severe and critically ill patients, effectively enhance immune function, shorten the length of hospital stay, and speed up the early improvement of the disease.
VL  - 10
IS  - 1
ER  -

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Author Information

Duan Li

Department of Laboratory Medicine, Xinjiang Medical University, The Eighth Affiliated Hospital, Urumqi, China
Qin Ying

Department of Laboratory Medicine, Xinjiang Medical University, The Eighth Affiliated Hospital, Urumqi, China
Li Yuanda

Department of Laboratory Medicine, Xinjiang Medical University, The Eighth Affiliated Hospital, Urumqi, China
Zhang Chi

Department of Laboratory Medicine, Xinjiang Medical University, The Eighth Affiliated Hospital, Urumqi, China
Qu Xiaojuan

Department of Laboratory Medicine, Xinjiang Medical University, The Eighth Affiliated Hospital, Urumqi, China
Wang Zifan

Department of Laboratory Medicine, Xinjiang Medical University, The Eighth Affiliated Hospital, Urumqi, China
Baishan•Hunapiya
Wang Fan

Department of Laboratory Medicine, Xinjiang Medical University, The Eighth Affiliated Hospital, Urumqi, China
Lin Zhiqiang

Department of Laboratory Medicine, Xinjiang Medical University, The Eighth Affiliated Hospital, Urumqi, China
Lin Guoyue

Department of Laboratory Medicine, Xinjiang Medical University, The Eighth Affiliated Hospital, Urumqi, China

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Plain Text BibTeX RIS

APA Style

Duan Li, Qin Ying, Li Yuanda, Zhang Chi, Qu Xiaojuan, et al. (2022). Study on the Changes of Antibody IgM and IgG Based on the Plasma Treatment of COVID-19 in Patients with New Coronary Pneumonia. Science Discovery, 10(1), 1-6. https://doi.org/10.11648/j.sd.20221001.11

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ACS Style

Duan Li; Qin Ying; Li Yuanda; Zhang Chi; Qu Xiaojuan, et al. Study on the Changes of Antibody IgM and IgG Based on the Plasma Treatment of COVID-19 in Patients with New Coronary Pneumonia. Sci. Discov. 2022, 10(1), 1-6. doi: 10.11648/j.sd.20221001.11

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AMA Style

Duan Li, Qin Ying, Li Yuanda, Zhang Chi, Qu Xiaojuan, et al. Study on the Changes of Antibody IgM and IgG Based on the Plasma Treatment of COVID-19 in Patients with New Coronary Pneumonia. Sci Discov. 2022;10(1):1-6. doi: 10.11648/j.sd.20221001.11

Copy | Download

@article{10.11648/j.sd.20221001.11,
  author = {Duan Li and Qin Ying and Li Yuanda and Zhang Chi and Qu Xiaojuan and Wang Zifan and Baishan•Hunapiya and Wang Fan and Lin Zhiqiang and Lin Guoyue},
  title = {Study on the Changes of Antibody IgM and IgG Based on the Plasma Treatment of COVID-19 in Patients with New Coronary Pneumonia},
  journal = {Science Discovery},
  volume = {10},
  number = {1},
  pages = {1-6},
  doi = {10.11648/j.sd.20221001.11},
  url = {https://doi.org/10.11648/j.sd.20221001.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20221001.11},
  abstract = {Objective To apply the convalescent plasma of recovered patients with new coronary pneumonia to treat COVID-19 to explore the changes of antibodies IgM and IgG in their bodies and the therapeutic effect. Methods Plasma treatment was performed for COVID-19, and the values of antibody IgM and IgG ct were observed and statistically analyzed. Results (1) 99 cases of rapid development, severe and critically ill patients were transfused with 107250ml plasma, 1083.33ml per capita. The effective rate of blood transfusion was 100% and the cure rate was 100%. (2) The 229 bags of convalescent plasma of the infused convalescent patients have an IgG ct value of 31.61±23.28 and an IgM of 7.19±11.94. (3) The antibody IgG and IgM ct values (68.70±69.14 and 47.89±64.63) of patients in the blood transfusion group were higher than the pre-transfusion ct values (4.46±13.99 and 4.46±13.99), and the differences were significant (p0.05), but the levels of antibody IgG and IgM in severe patients in the blood transfusion group were significantly higher than those in the non-transfusion group (P<0.05). (4) The hospitalization days of the fast-growing and severe patients in the blood transfusion group were significantly shorter than those in the non-transfusion group (P<0.05). Conclusion The application of convalescent plasma from patients recovering from new coronary pneumonia to treat COVID-19 can greatly increase the antibody content in severe and critically ill patients, effectively enhance immune function, shorten the length of hospital stay, and speed up the early improvement of the disease.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Study on the Changes of Antibody IgM and IgG Based on the Plasma Treatment of COVID-19 in Patients with New Coronary Pneumonia
AU  - Duan Li
AU  - Qin Ying
AU  - Li Yuanda
AU  - Zhang Chi
AU  - Qu Xiaojuan
AU  - Wang Zifan
AU  - Baishan•Hunapiya
AU  - Wang Fan
AU  - Lin Zhiqiang
AU  - Lin Guoyue
Y1  - 2022/01/08
PY  - 2022
N1  - https://doi.org/10.11648/j.sd.20221001.11
DO  - 10.11648/j.sd.20221001.11
T2  - Science Discovery
JF  - Science Discovery
JO  - Science Discovery
SP  - 1
EP  - 6
PB  - Science Publishing Group
SN  - 2331-0650
UR  - https://doi.org/10.11648/j.sd.20221001.11
AB  - Objective To apply the convalescent plasma of recovered patients with new coronary pneumonia to treat COVID-19 to explore the changes of antibodies IgM and IgG in their bodies and the therapeutic effect. Methods Plasma treatment was performed for COVID-19, and the values of antibody IgM and IgG ct were observed and statistically analyzed. Results (1) 99 cases of rapid development, severe and critically ill patients were transfused with 107250ml plasma, 1083.33ml per capita. The effective rate of blood transfusion was 100% and the cure rate was 100%. (2) The 229 bags of convalescent plasma of the infused convalescent patients have an IgG ct value of 31.61±23.28 and an IgM of 7.19±11.94. (3) The antibody IgG and IgM ct values (68.70±69.14 and 47.89±64.63) of patients in the blood transfusion group were higher than the pre-transfusion ct values (4.46±13.99 and 4.46±13.99), and the differences were significant (p0.05), but the levels of antibody IgG and IgM in severe patients in the blood transfusion group were significantly higher than those in the non-transfusion group (P<0.05). (4) The hospitalization days of the fast-growing and severe patients in the blood transfusion group were significantly shorter than those in the non-transfusion group (P<0.05). Conclusion The application of convalescent plasma from patients recovering from new coronary pneumonia to treat COVID-19 can greatly increase the antibody content in severe and critically ill patients, effectively enhance immune function, shorten the length of hospital stay, and speed up the early improvement of the disease.
VL  - 10
IS  - 1
ER  -

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